1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

Base Information

Chemical Name:1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile
CAS No.:145355-20-0
Molecular Formula:C₂₂H₂₆N₆O₂
Molecular Weight:406.487
Hs Code.:

Synonyms:1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

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Chemical Property of 1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

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Technology Process of 1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

There total 6 articles about 1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144062-65-7
1-<4-<(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl>phenyl>-1H-pyrrole-2-carbonitrile

: 145355-20-0
1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

Guidance literature:: With nitric acid; acetic anhydride; at -20 - 20 ℃; for 7h;
DOI:10.1021/jm00053a013

Reference yield:

: 827-60-1
1-(4-methylphenyl)-1H-pyrrole

: 145355-20-0
1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: POCl₃ / 3 h / 110 - 120 °C

2: 1.) H₂NOH*HCl/Na₂CO₃, 2.) Ac₂O / 1.) MeOH, H₂O, reflux, 3 h, 2.) reflux, 3 h

3: 65 percent Spectr_. / N-bromosuccinimide, AIBN / CCl₄ / 3 h

4: 1.) NaH / 1.) DMF, 2.) DMF, -10 deg C to RT

5: 70percent HNO₃, Ac₂O / 7 h / -20 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; nitric acid; acetic anhydride; sodium hydride; sodium carbonate; trichlorophosphate; In tetrachloromethane;
DOI:10.1021/jm00053a013

Reference yield:

: 30186-38-0
1-(4-methylphenyl)-2-formyl-1H-pyrrole

: 145355-20-0
1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂NOH*HCl/Na₂CO₃, 2.) Ac₂O / 1.) MeOH, H₂O, reflux, 3 h, 2.) reflux, 3 h

2: 65 percent Spectr_. / N-bromosuccinimide, AIBN / CCl₄ / 3 h

3: 1.) NaH / 1.) DMF, 2.) DMF, -10 deg C to RT

4: 70percent HNO₃, Ac₂O / 7 h / -20 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; nitric acid; acetic anhydride; sodium hydride; sodium carbonate; In tetrachloromethane;
DOI:10.1021/jm00053a013