11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

Base Information

Chemical Name:11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
CAS No.:28781-44-4
Molecular Formula:C₂₅H₂₅N₅O₂
Molecular Weight:427.506
Hs Code.:

11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[<i>e</i>]pyrido[3,2-<i>b</i>][1,4]diazepin-6-one

Synonyms:11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

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Chemical Property of 11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

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Technology Process of 11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

There total 5 articles about 11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100-39-0
benzyl bromide

: 63257-31-8,122859-63-6
N-Demethyl-Pirenzepin

: 28781-44-4
11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

Guidance literature:: With triethylamine; In tetrahydrofuran; methanol; at 25 - 40 ℃;
DOI:10.1021/jm00111a032

Reference yield:

: 29868-97-1,93173-05-8
pirenzepine dihydrochloride

: 28781-44-4
11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) α-chloroethyl chloroformate, N,N,N-diisopropylethylamine, 2.) 1 M HCl in ether / 1.) chloroform, reflux, 1 h, 2.) methanol, reflux, 3 h

2: 98 percent / triethylamine / tetrahydrofuran; methanol / 25 - 40 °C

With hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm00111a032

Reference yield:

: 28797-48-0
11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

: 28781-44-4
11-[(4-benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: dioxane / 1 h / Heating

2: 98 percent / triethylamine / tetrahydrofuran; methanol / 25 - 40 °C

With triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm00111a032