N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide

Base Information

• Chemical Name: N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide
• CAS No.: 1355554-31-2
• Molecular Formula: C₁₇H₂₂N₂O₄S
• Molecular Weight: 350.439
• Mol file: 1355554-31-2.mol

Synonyms:N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide

Chemical Property of N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide

There total 10 articles about N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzene-1-sulfonyl chloride (1227693-30-2) + Cyclopentamine (1003-03-8) → N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide (1355554-31-2)

Guidance literature:

With pyridine; at 25 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bioorg.2021.104849

Reference yield: 72.0%

N-cyclopentyl-N-(2,4-dimethoxybenzyl)-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide → N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide (1355554-31-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1039/c4md00182f

Reference yield:

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole (832114-00-8) + 5-bromo-N-cyclopentyl-2-methoxybenzenesulfonamide (915930-21-1) → N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide (1355554-31-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h;

DOI:10.1021/jm201283q

upstream raw materials:

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

5-bromo-N-cyclopentyl-2-methoxybenzenesulfonamide

5-bromo-2-methoxybenzenesulfonyl chloride

Cyclopentamine

Downstream raw materials:

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(3-morpholinopropoxy) benzene sulfonamide

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(2-(piperazin-1-yl)ethoxy)benzenesulfonamide

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(3-morpholinopropoxy)benzenesulfonamide hydrochloride