N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide

Base Information

• Chemical Name: N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide
• CAS No.: 1355554-13-0
• Molecular Formula: C₁₆H₂₀N₂O₄S
• Molecular Weight: 336.412
• Mol file: 1355554-13-0.mol

Synonyms:N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide

Chemical Property of N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide

There total 8 articles about N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide (1355554-31-2) → N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide (1355554-13-0)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/jm201283q

Reference yield:

3,5-dimethyl-4-[4-(methyloxy)phenyl]isoxazole (154822-66-9) → N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide (1355554-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorosulfonic acid / dichloromethane / 6.5 h / 20 °C / Cooling

2: ethyl acetate / 6 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 2 h / 0 - 20 °C

With chlorosulfonic acid; boron tribromide; In dichloromethane; ethyl acetate;

Reference yield:

5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzene-1-sulfonyl chloride (1227693-30-2) → N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide (1355554-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate / 6 h / 20 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 2 h / 0 - 20 °C

With boron tribromide; In dichloromethane; ethyl acetate;

upstream raw materials:

5-bromo-N-cyclopentyl-2-methoxybenzenesulfonamide

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide

5-bromo-2-methoxybenzenesulfonyl chloride

Cyclopentamine

Downstream raw materials:

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(3-morpholinopropoxy) benzene sulfonamide

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(3-morpholinopropoxy)benzenesulfonamide hydrochloride

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(2-(piperazin-1-yl)ethoxy)benzenesulfonamide

N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-(2-(piperazin-1-yl)ethoxy)benzenesulfonamide hydrochloride