(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

Base Information

Chemical Name:(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester
CAS No.:74595-20-3
Molecular Formula:C₃₉H₅₇NO₉Si
Molecular Weight:711.968
Hs Code.:

(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

Synonyms:(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

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Chemical Property of (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

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Technology Process of (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

There total 13 articles about (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(4S,6R)-2,2-dimethyl-6-[(Z)-2-nitro-3-(2-pentyl-[1,3]dioxolan-2-yl)-propenyl]-[1,3]dioxan-4-yl}-oct-5-enoic acid methyl ester

: 74595-20-3
(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

: 80102-63-2
(5Z,12Z)-(8R,9S,11R)-8-(tert-Butyl-diphenyl-silanyloxy)-9,11-dihydroxy-13-nitro-14-(2-pentyl-[1,3]dioxolan-2-yl)-tetradeca-5,12-dienoic acid methyl ester

Guidance literature:: With hydrogenchloride; In methanol; water; for 2h; Ambient temperature;
DOI:10.1139/v81-394

Reference yield:

: 74581-59-2
methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-12-oxo-dodeca-5Z-enoate

: 74595-20-3
(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / diisopropylamine / dimethylformamide / Ambient temperature

2: triethylamine, 4-dimethylaminopyridine / diethyl ether / 0.5 h / Ambient temperature

3: 95 percent / K₂CO₃, dicyclohexyl-18-crown-6 / benzene / 6 h / 75 °C

4: 60 percent / 2N HCl / H₂O; methanol / 2 h / Ambient temperature

With hydrogenchloride; dmap; perhydrodibenzo-18-crown-6; potassium carbonate; triethylamine; diisopropylamine; In methanol; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1139/v81-394

Reference yield:

: 74581-60-5
1-nitro-octan-3-one ethylene ketal

: 74595-20-3
(Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-{(2S,4R)-4-hydroxy-5-[1-nitro-2-(2-pentyl-[1,3]dioxolan-2-yl)-ethyl]-tetrahydro-furan-2-yl}-oct-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / diisopropylamine / dimethylformamide / Ambient temperature

2: triethylamine, 4-dimethylaminopyridine / diethyl ether / 0.5 h / Ambient temperature

3: 95 percent / K₂CO₃, dicyclohexyl-18-crown-6 / benzene / 6 h / 75 °C

4: 60 percent / 2N HCl / H₂O; methanol / 2 h / Ambient temperature

With hydrogenchloride; dmap; perhydrodibenzo-18-crown-6; potassium carbonate; triethylamine; diisopropylamine; In methanol; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1139/v81-394