methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Base Information

Chemical Name:methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate
CAS No.:80126-58-5
Molecular Formula:C₃₇H₅₂O₆Si
Molecular Weight:620.902
Hs Code.:

Synonyms:methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Suppliers and Price of methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

There total 15 articles about methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 74581-63-8
methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-13-nitro-15-oxo-9S,12S-oxyeicosa-5Z-enoate

: 80126-58-5
methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Guidance literature:: With triethylamine; In chloroform; Ambient temperature;
DOI:10.1139/v81-394

Reference yield:

: 74581-60-5
1-nitro-octan-3-one ethylene ketal

: 80126-58-5
methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / diisopropylamine / dimethylformamide / Ambient temperature

2: triethylamine, 4-dimethylaminopyridine / diethyl ether / 0.5 h / Ambient temperature

3: 95 percent / K₂CO₃, dicyclohexyl-18-crown-6 / benzene / 6 h / 75 °C

4: 60 percent / 2N HCl / H₂O; methanol / 2 h / Ambient temperature

5: 80 percent / p-toluenesulfonic acid / acetone / Ambient temperature

6: 85 percent / triethylamine / CHCl₃ / Ambient temperature

With hydrogenchloride; dmap; perhydrodibenzo-18-crown-6; potassium carbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; In methanol; diethyl ether; chloroform; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1139/v81-394

Reference yield:

: 74581-59-2
methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-12-oxo-dodeca-5Z-enoate

: 80126-58-5
methyl 8R-tert-butyldiphenylsilyloxy-11R-hydroxy-15-oxo-9S,12S-oxyeicosa-5Z,13E-dienoate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / diisopropylamine / dimethylformamide / Ambient temperature

2: triethylamine, 4-dimethylaminopyridine / diethyl ether / 0.5 h / Ambient temperature

3: 95 percent / K₂CO₃, dicyclohexyl-18-crown-6 / benzene / 6 h / 75 °C

4: 60 percent / 2N HCl / H₂O; methanol / 2 h / Ambient temperature

5: 80 percent / p-toluenesulfonic acid / acetone / Ambient temperature

6: 85 percent / triethylamine / CHCl₃ / Ambient temperature

With hydrogenchloride; dmap; perhydrodibenzo-18-crown-6; potassium carbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; In methanol; diethyl ether; chloroform; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1139/v81-394