ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate

Base Information

• Chemical Name: ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate
• CAS No.: 1161361-96-1
• Molecular Formula: C₁₃H₁₄BrNO₂
• Molecular Weight: 296.164
• Mol file: 1161361-96-1.mol

Synonyms:ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate

Chemical Property of ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate

There total 1 articles about ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dibromotoluene (1611-92-3) + ethyl 2-cyanoacetate (105-56-6) + methyl iodide (74-88-4) → ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate (1161361-96-1)

Guidance literature:

3,5-dibromotoluene; ethyl 2-cyanoacetate; With potassium tert-butylate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; at 70 ℃; for 1h;

methyl iodide; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

ethyl 2-(3-bromo-5-methylphenyl)-2-cyanopropanoate (1161361-96-1) → 2-(3-bromo-5-methylphenyl)propanenitrile (1161361-97-2)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 100 ℃;

upstream raw materials:

3,5-dibromotoluene

ethyl 2-cyanoacetate

methyl iodide

Downstream raw materials:

2-(3-bromo-5-methylphenyl)propanenitrile