tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane
CAS No.:132474-38-5
Molecular Formula:C₂₃H₃₂O₃Si
Molecular Weight:384.591
Hs Code.:

Synonyms:tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

Suppliers and Price of tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

There total 1 articles about tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 132474-37-4,132474-42-1
1-(2-Ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-yn-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 132474-38-5
tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(00)88509-3

Reference yield: 94.0%

: 81790-10-5
(2-bromoallyl)trimethylsilane

: 132474-38-5
tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

: 132474-39-6
2-{4-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-phenyl]-but-2-ynyloxy}-tetrahydro-pyran

Guidance literature:: With diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1016/S0040-4039(00)88509-3

Reference yield:

: 132474-38-5
tert-Butyl-[1-(2-ethynyl-phenyl)-4-(tetrahydro-pyran-2-yloxy)-but-2-ynyloxy]-dimethyl-silane

: 132474-41-0
4-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-phenyl]-but-2-ynal

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / iPr₂NH / Pd(PPh₃)3Cl₂/CuI / tetrahydrofuran / 4 h / 20 °C

2: 81 percent / PPTS / propan-2-ol / 20 °C

3: 1) tBuOMgBr, 2) 1,1-(azodicarbonyl)dipiperidide / 1) THF, -25 deg C, 2) up to 20 deg C

With 1,1'-carbonyldipiperidine; bromomagnesium t-butoxide; pyridinium p-toluenesulfonate; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/S0040-4039(00)88509-3