3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

Base Information

Chemical Name:3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole
CAS No.:935248-22-9
Molecular Formula:C₂₀H₁₈Cl₂N₂O₂
Molecular Weight:389.281
Hs Code.:

Synonyms:3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

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Chemical Property of 3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

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Technology Process of 3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

There total 8 articles about 3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 935248-21-8
{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-ethanol

: 935248-22-9
3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

Guidance literature:: With thionyl chloride; In 1,2-dichloro-ethane; at 50 ℃; for 40h;
DOI:10.1016/j.bmcl.2006.12.109

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 935248-22-9
3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: 84 percent / aluminum chloride / toluene / 0.5 h / Heating

2.1: 63 percent / potassium carbonate / tetrabutylammonium iodide / acetonitrile / 40 h / 60 - 65 °C

3.1: 100 percent / sodium borohydride / methanol / 1 h / 20 °C

4.1: 100 percent / thionyl chloride / toluene / 1.5 h / 20 - 60 °C

5.1: 82 percent / potassium t-butoxide / tetrahydrofuran / 60 h / 60 °C

6.1: dioxane / 80 °C

6.2: aq. HCl / 18 h / 90 - 95 °C

7.1: 220 mg / borane methyl sulfide / tetrahydrofuran / 20 h / 20 °C

8.1: 95 percent / thionyl chloride / 1,2-dichloro-ethane / 40 h / 50 °C

With sodium tetrahydroborate; aluminium trichloride; thionyl chloride; dimethylsulfide borane complex; potassium tert-butylate; potassium carbonate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.109

Reference yield:

: 62803-47-8
6-hydroxy-1-indanone

: 935248-22-9
3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 63 percent / potassium carbonate / tetrabutylammonium iodide / acetonitrile / 40 h / 60 - 65 °C

2.1: 100 percent / sodium borohydride / methanol / 1 h / 20 °C

3.1: 100 percent / thionyl chloride / toluene / 1.5 h / 20 - 60 °C

4.1: 82 percent / potassium t-butoxide / tetrahydrofuran / 60 h / 60 °C

5.1: dioxane / 80 °C

5.2: aq. HCl / 18 h / 90 - 95 °C

6.1: 220 mg / borane methyl sulfide / tetrahydrofuran / 20 h / 20 °C

7.1: 95 percent / thionyl chloride / 1,2-dichloro-ethane / 40 h / 50 °C

With sodium tetrahydroborate; thionyl chloride; dimethylsulfide borane complex; potassium tert-butylate; potassium carbonate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.109