4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one

Base Information

• Chemical Name: 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one
• CAS No.: 1402464-78-1
• Molecular Formula: C₁₆H₁₂Cl₂N₂OS
• Molecular Weight: 351.256
• Mol file: 1402464-78-1.mol

Synonyms:4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one

Chemical Property of 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one

There total 2 articles about 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(p-chlorophenyl)-3-(p-chlorophenyl)-2,3-epoxy-1-propanone (29425-79-4) + thiourea (17356-08-0) → 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one (1402464-78-1)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Reflux;

DOI:10.1002/ardp.201200119

Reference yield:

(E)-1,3-di(4-chlorophenyl)-2-propen-1-one (19672-59-4,20725-25-1,22966-30-9) → 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one (1402464-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide; sodium hydroxide / methanol; acetone / 20 - 25 °C

2: potassium hydroxide / ethanol / 4 h / Reflux

With dihydrogen peroxide; potassium hydroxide; sodium hydroxide; In methanol; ethanol; acetone;

DOI:10.1002/ardp.201200119

Reference yield: 79.0%

piperidine (110-89-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one (1402464-78-1) → C22H23Cl2N3OS (1402464-86-1)

Guidance literature:

formaldehyd; 4,6-bis(4-chlorophenyl)-2-thioxo-tetrahydropyrimidin-5-one; In ethanol; for 5h; Heating;

piperidine; In ethanol; at 20 ℃; for 3h;

DOI:10.1002/ardp.201200119

upstream raw materials:

(E)-1,3-di(4-chlorophenyl)-2-propen-1-one

1-(p-chlorophenyl)-3-(p-chlorophenyl)-2,3-epoxy-1-propanone

thiourea

Downstream raw materials:

4,6-bis(4-chloro-phenyl)-2-(methylthio)-pyrimidin-5(4H)-one

C₁₈H₁₂Cl₂N₂O₂S

2-benzylidine-5,7-bis(4-chlorophenyl)-5H,7H-thiazolo[3,2-a]pyrimidine-3,6-dione

C₂₅H₁₅Cl₂N₃O₂S