29425-79-4

Upstream product

• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 
• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 
• 1073-67-2 4-vinylbenzyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 52578-08-2 2,3-bis-(4-chloro-phenyl)-3-oxo-propionaldehyde 
• 395-19-7 (2RS,3RS)-1,3-bis-(4-chloro-phenyl)-3-fluoro-2-hydroxy-propan-1-one 
• 21399-29-1 3,5-bis(4-chlorophenyl)-1H-pyrazole 
• 20724-87-2 trans-2-Chlor-3-oxo-1,3-bis-(4-chlor-phenyl)-propen-⁽¹⁾ 
• 1402464-85-0 C₂₅H₁₅Cl₂N₃O₂S 
• 1402464-86-1 C₂₂H₂₃Cl₂N₃OS 
• 1402464-87-2 [4,6-bis(4-chlorophenyl)-5-oxo-4,5-dihydropyrimidin-2-yloxy]acetic acid ethyl ester 
• 1402464-88-3 5,7-bis(4-chlorophenyl)tetrazolo[1,5-a]pyrimidin-6-one 
• 1402464-89-4 2-amino-4,6-bis(4-chlorophenyl)pyrimidin-5(4H)-one 
• 1402464-90-7 C₁₇H₁₀Cl₂N₄OS 
• 1402464-91-8 3-chloromethyl-5,7-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyrimidin-6-one 
• 1402464-92-9 5,7-bis(4-chlorophenyl)-3-methyl-[1,2,4]triazolo[4,3-a]pyrimidin-6-one 
• 1402464-93-0 5,7-bis(4-chlorophenyl)-3-phenyl-[1,2,4]triazolo[4,3-a]pyrimidin-6-one 
• 1402464-81-6 4,6-bis(4-chloro-phenyl)-2-(methylthio)-pyrimidin-5(4H)-one 

Relevant academic research and scientific papers

Ligand regulation for manganese-catalyzed enantioselective epoxidation of olefins without acid

A novel manganese catalyst bearing an l-proline-derived N4 ligand has been developed for enabling acid-free asymmetric epoxidation of olefins with tert-butyl hydroperoxide as the oxidant. A variety of olefins that are well-matched in size with the ligand

Facile epoxidation of α, β-unsaturated ketones with urea-2,2-dihydroperoxypropane as a new oxidant

Abstract: Various aromatic α, β-unsaturated ketones were successfully transformed into their corresponding epoxides using urea-2,2-dihydroperoxypropane as the oxygen source for the first time. The reactions were carried out under mild alkaline conditions at room temperature in high yields and short reaction times. Graphical Abstract: [Figure not available: see fulltext.]

Metal-Free and Efficient Epoxidation of α,β-Unsaturated Ketones with 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as a Powerful Solid Oxidant

1,1,2,2-Tetrahydroperoxy-1,2-diphenylethane was used for the efficient and metal-free epoxidation of various α,β-unsaturated ketones, carried out under mild alkaline conditions at room temperature.

Asymmetric Epoxidation of Olefins with H2O2 Catalyzed by a Bioinspired Aminopyridine N4 Iron Complex

An iron complex with a chiral aminopyridine N4 ligand bearing strong electron-donating and bulky morpholine groups on the ligand is synthesized and characterized. The iron complex serves to efficiently catalyze the asymmetric epoxidation of various olefins by employing aqueous hydrogen peroxide as the green oxidant, providing the corresponding epoxides in good to excellent yields and enantioselectivities (up to 93 % yield and 99.9 % ee). Owing to the introduction of morpholine functional groups on the ligand, the Fe-catalyzed reaction can proceed with a catalytic amount of the carboxylic acid partner (3 mol %).

epoxy Zha Tong and a method for its synthesis of derivatives

The invention belongs to the technical field of organic compound synthesis. In order to solve the problem of potential safety hazards in the preparation of existing epoxy compounds, the invention provides a synthesis method of epoxy chalcone and derivatives thereof. Substituted chalcone used as an initiator reacts in a solvent at 0-50 DEG C for 0.5-6 hours in the presence of a catalyst and an oxidizer to obtain the epoxy chalcone and derivatives thereof. The method is safe and easy to implement, has the advantages of cheap and accessible catalyst, low toxicity, mild reaction conditions, favorable functional group universality and the like, and is simple to operate.

Oxidative coupling of alkenes with aldehydes and hydroperoxides: One-pot synthesis of 2,3-epoxy Ketones

A new transition metal-free oxidative coupling of unactivated terminal alkenes with aldehydes and hydroperoxides in the presence of 10 mol% potassium tert-butanolate (t-BuOK) is described thereby realizing trifunctionalization of alkenes toward 2,3-epoxy ketones. This method is applicable to a wide range of aldehydes, including aryl and alkyl aldehydes, with excellent functional group tolerance, and provides for the one-step assembly of 2,3-epoxy ketones.

Visible-Light-Promoted Photoredox Syntheses of α,β-Epoxy Ketones from Styrenes and Benzaldehydes under Alkaline Conditions

A range of styrenes and benzaldehydes were smoothly combined to form α,β-epoxy ketones under the synergistic actions of photocatalyst Ru(bpy)3Cl2, tert-butyl hydroperoxide (t-BuOOH), cesium carbonate (Cs2CO3), and visible light irradiation. The process likely proceeds through visible-light-enabled photocatalytic generations of acyl radicals as key intermediates.

Regioselective opening of chalcone epoxides with nitrogen heterocycles using indium(III) chloride as an efficient catalyst

Indium(III) chloride catalyzes regioselective ring opening of chalcone epoxides with nitrogen heterocycles such as indole, 2-methyl indole, and pyrrole under mild conditions at room temperature to afford 1,3-diaryl-2-hydroxy-3-(1H- 3-indolyl/2-pyrrolyl)propan-1-ones in good yields (60-88%) within 20-50 min. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.

New pyrimidinone and fused pyrimidinone derivatives as potential anticancer chemotherapeutics

A series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3-18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF-7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF-7 cell line comparable to the activity of the commonly used anticancer drug cisplatin. Treatment of MCF-7 cells with increasing doses (2, 5, 10, and 20 μg/mL) of the tested compounds revealed that the activity of superoxide dismutase and the level of hydrogen peroxide were significantly increased, while the activities of catalase and glutathione peroxidase and the levels of reduced glutathione were significantly lowered compared with control MCF-7 cells. In general, derivatives 11 and 16 revealed the highest anticancer activity among the tested compounds.

Manganese catalysts with C1-symmetric N4 ligand for enantioselective epoxidation of olefins

Bioinspired manganese complexes based on N4 ligands, with a more rigid, chiral diamine derived from proline and two benzimidazoles, were synthesized and applied to epoxidize olefins with hydrogen peroxide as a clean oxidant. Notably, 60-99 % isolated yields and excellent ee values (up to 95 %) were obtained by using low catalyst loadings (0.01-0.2 mol %; see scheme; F green, S yellow). Copyright