Technology Process of L-leucyl-3-hydroxy-L-tyrosine
There total 4 articles about L-leucyl-3-hydroxy-L-tyrosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; trifluoroacetic acid;
for 24h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: HClO4
2: 70 percent / NEt3, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 18 h / Ambient temperature
3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH2Cl2, -15 deg C, 5 min, 2.) CH2Cl2, r.t., 24 h
4: 95 percent / 95percent CF3COOH/H2O / 24 h / Ambient temperature
With
4-methyl-morpholine; perchloric acid; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 70 percent / NEt3, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 18 h / Ambient temperature
2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH2Cl2, -15 deg C, 5 min, 2.) CH2Cl2, r.t., 24 h
3: 95 percent / 95percent CF3COOH/H2O / 24 h / Ambient temperature
With
4-methyl-morpholine; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
In
acetonitrile;