1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester
• CAS No.: 945546-53-2
• Molecular Formula: C₁₈H₂₁IO₂
• Molecular Weight: 396.268
• Mol file: 945546-53-2.mol

Synonyms:1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester

Chemical Property of 1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester

There total 1 articles about 1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tert-butyl cyclohexa-1,4-diene-3-carboxylate (61812-52-0) + 2-Iodobenzyl bromide (40400-13-3) → 1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester (945546-53-2)

Guidance literature:

tert-butyl cyclohexa-1,4-diene-3-carboxylate; With ammonium hydroxide; lithium; In tetrahydrofuran; methanol; at -78 ℃; for 0.166667h; Inert atmosphere;

2-Iodobenzyl bromide; In tetrahydrofuran; methanol; at -78 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1039/c9cc01379b

Reference yield: 84.0%

1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester (945546-53-2) + malonic acid dibenzyl ester (15014-25-2) → dibenzyl 2-((3S,4aR,9aS)-9a-(tert-butoxycarbonyl)-4,4a,9,9a-tetrahydro-3H-fluoren-3-yl)malonate

Guidance literature:

With C₅₃H₃₃F₁₇NO₂P; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 25 ℃; for 48h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c9cc01379b

Reference yield: 80.0%

1-(2-iodobenzyl)cyclohexa-2,5-dienecarboxylic acid tert-butyl ester (945546-53-2) → 1-(2-iodobenzyl)-4-oxocyclohexa-2,5-dienecarboxylic acid tert-butyl ester (945546-55-4)

Guidance literature:

With chromium(VI) oxide; acetic anhydride; acetic acid; In benzene; at 7 ℃; for 2h;

DOI:10.1021/ol070849l

upstream raw materials:

tert-butyl cyclohexa-1,4-diene-3-carboxylate

2-Iodobenzyl bromide

Downstream raw materials:

1-(2-iodobenzyl)-4-oxocyclohexa-2,5-dienecarboxylic acid tert-butyl ester