5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

Base Information

Chemical Name:5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione
CAS No.:125531-65-9
Molecular Formula:C₂₇H₂₂N₂O₄S
Molecular Weight:470.549
Hs Code.:

Synonyms:5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

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Chemical Property of 5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

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Technology Process of 5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

There total 4 articles about 5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-{4-[(E)-3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

: 125531-65-9
5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

Guidance literature:: With triethylsilane; In trifluoroacetic acid; at 0 ℃;
DOI:10.1021/jm00088a022

Reference yield:

: 18910-19-5
4-acetyl-alpha-bromobenzenepropanoic acid

: 125531-65-9
5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sulfolane, 2.) HCl / 1.) 110 deg C, 5 h, 2.) 110 deg C, overnight

2: NaOMe / ethanol

3: triethylsilane / trifluoroacetic acid / 0 °C

With sulfolane; hydrogenchloride; triethylsilane; sodium methylate; In ethanol; trifluoroacetic acid;
DOI:10.1021/jm00088a022

Reference yield:

: 5-Methyl-2-naphthalen-2-yl-oxazole-4-carbaldehyde

: 125531-65-9
5-{4-[3-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / ethanol

2: triethylsilane / trifluoroacetic acid / 0 °C

With triethylsilane; sodium methylate; In ethanol; trifluoroacetic acid;
DOI:10.1021/jm00088a022