N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

Base Information

Chemical Name:N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide
CAS No.:251643-50-2
Molecular Formula:C₂₇H₃₇N₅O₇
Molecular Weight:543.62
Hs Code.:

Synonyms:N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

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Chemical Property of N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

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Technology Process of N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

There total 17 articles about N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-00-9
N,N-dimethylethylenediamine

: C₂₇H₂₉N₅O₉

: 251643-50-2
N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1039/a904067f

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 251643-50-2
N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / DMAP / tetrahydrofuran / 48 h / Heating

2: 99 percent / LiOH; H₂O / methanol / 0.5 h / 50 °C

3: 41 percent / BH₃*DMS / tetrahydrofuran / 3 h / 2 °C

4: benzene; tetrahydrofuran / 16 h / 20 °C

5: CS₂CO₃ / dimethylformamide / 16 h / 20 °C

6: 90 percent / NaOH; H₂O / methanol / 1 h / 20 °C

7: dimethylformamide / 0.17 h / 50 °C

8: 80 percent / dimethylformamide / 2 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; dimethylsulfide borane complex; water; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: Hydrolysis / 3: Reduction / 4: Substitution / 5: Acylation / 6: Hydrolysis / 7: Substitution / 8: Acylation;
DOI:10.1039/a904067f

Reference yield:

: 3558-13-2
4-nitro-2-methylaminobenzoic acid methyl ester

: 251643-50-2
N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / DMAP / tetrahydrofuran / 48 h / Heating

2: 99 percent / LiOH; H₂O / methanol / 0.5 h / 50 °C

3: 41 percent / BH₃*DMS / tetrahydrofuran / 3 h / 2 °C

4: benzene; tetrahydrofuran / 16 h / 20 °C

5: CS₂CO₃ / dimethylformamide / 16 h / 20 °C

6: 90 percent / NaOH; H₂O / methanol / 1 h / 20 °C

7: dimethylformamide / 0.17 h / 50 °C

8: 80 percent / dimethylformamide / 2 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; dimethylsulfide borane complex; water; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: Hydrolysis / 3: Reduction / 4: Substitution / 5: Acylation / 6: Hydrolysis / 7: Substitution / 8: Acylation;
DOI:10.1039/a904067f