3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

Base Information

Chemical Name:3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol
CAS No.:1202463-52-2
Molecular Formula:C₁₈H₁₄F₄N₂O₃
Molecular Weight:382.314
Hs Code.:

Synonyms:3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

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Chemical Property of 3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

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Technology Process of 3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

There total 4 articles about 3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1202463-83-9
3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propanoic acid

: 1202463-52-2
3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

Guidance literature:: 3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propanoic acid; With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

With water; In tetrahydrofuran;

Reference yield:

: 913287-12-4
ethyl 5-fluoro-7-nitro-1H-indole-2-carboxyiate

: 1202463-52-2
3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / Reflux

1.2: pH 2

2.1: quinoline / 2 h / 205 °C

3.1: acetonitrile / 48 h / Reflux

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With lithium borohydride; potassium hydroxide; quinoline; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 1202463-81-7
5-fluoro-7-nitro-1H-indole-2-carboxylic acid

: 1202463-52-2
3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: quinoline / 2 h / 205 °C

2: acetonitrile / 48 h / Reflux

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With lithium borohydride; quinoline; In tetrahydrofuran; acetonitrile;