N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

Base Information

Chemical Name:N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide
CAS No.:1202463-53-3
Molecular Formula:C₂₀H₁₇F₄N₃O₂S
Molecular Weight:439.433
Hs Code.:

Synonyms:N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

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Chemical Property of N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

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Technology Process of N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

There total 5 articles about N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: potassium cyanide

: 1202463-52-2
3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

: 124-63-0
methanesulfonyl chloride

: 1202463-53-3
N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

Guidance literature:: 3-(5-Fluoro-7-nitro-1H-indol-3-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol; With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

methanesulfonyl chloride; With triethylamine; dmap; In dichloromethane; at 20 ℃; Inert atmosphere;

potassium cyanide; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 913287-12-4
ethyl 5-fluoro-7-nitro-1H-indole-2-carboxyiate

: 1202463-53-3
N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol / Reflux

1.2: pH 2

2.1: quinoline / 2 h / 205 °C

3.1: acetonitrile / 48 h / Reflux

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

5.2: 20 °C / Inert atmosphere

5.3: 80 °C

With lithium borohydride; hydrogen; potassium hydroxide; quinoline; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 1202463-81-7
5-fluoro-7-nitro-1H-indole-2-carboxylic acid

: 1202463-53-3
N-(3-{3-Cyano-1-[4-(trifluoromethyl)phenyl]propyl}-5-fluoro-1H-indol-7-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: quinoline / 2 h / 205 °C

2.1: acetonitrile / 48 h / Reflux

3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4.2: 20 °C / Inert atmosphere

4.3: 80 °C

With lithium borohydride; hydrogen; quinoline; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; acetonitrile;