tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Base Information

• Chemical Name: tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate
• CAS No.: 865135-74-6
• Molecular Formula: C₄₀H₄₉FN₂O₇SSi
• Molecular Weight: 748.988
• Mol file: 865135-74-6.mol

Synonyms:tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Chemical Property of tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

There total 8 articles about tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methanol (858096-63-6) + tert-butyl 3-(2-fluoro-4-{[(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate (865138-42-7) → tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate (865135-74-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃;

DOI:10.1021/jm2016123

Reference yield:

4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde (805250-31-1) → tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate (865135-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4 h

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

With 1H-imidazole; sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm2016123

Reference yield:

4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde (858096-62-5) → tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate (865135-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

With sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/jm2016123

upstream raw materials:

4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

(4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methanol

tert-butyl 3-(2-fluoro-4-{[(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate

4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde

Downstream raw materials:

C₃₈H₄₃FN₂O₉S₂

C₃₂H₄₀FNO₅S

tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

tert-butyl 3-{4-[({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoate