tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Base Information

Chemical Name:tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate
CAS No.:865136-48-7
Molecular Formula:C₃₉H₄₃FN₂O₉S₂
Molecular Weight:766.909
Hs Code.:

tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Synonyms:tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

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Chemical Property of tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

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Technology Process of tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

There total 12 articles about tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 865136-47-6
tert-butyl 3-[4-({[2',6'-dimethyl-4'-(tetrahydro-2H-thiopyran-4-yloxy)biphenyl-3-yl]methyl}[(2-nitrophenyl)sulfonyl]amino)-2-fluorophenyl]propanoate

: 865136-48-7
tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In ethyl acetate; at 0 - 20 ℃; for 16h;
DOI:10.1021/jm2016123

Reference yield:

: 805250-31-1
4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

: 865136-48-7
tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4 h

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

5: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 16 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016123

Reference yield:

: 858096-63-6
(4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methanol

: 865136-48-7
tert-butyl 3-(4-{({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 16 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jm2016123