N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

Base Information

Chemical Name:N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide
CAS No.:1448793-05-2
Molecular Formula:C₂₀H₁₇F₄N₅O₂
Molecular Weight:435.381
Hs Code.:

Synonyms:N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

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Chemical Property of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

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Technology Process of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

There total 8 articles about N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262860-49-0
5-cyano-3-methyl-pyridine-2-carboxylic acid

: 1432511-78-8
(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1448793-05-2
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 25 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1432511-76-6
(4S,6S)-4-(2-fluoro-5-nitrophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1448793-05-2
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen; triethylamine / ethanol / 2 h / 22 °C

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 20 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethanol; ethyl acetate;

Reference yield:

: 1432511-68-6
3-methyl-5-(trifluoromethyl)-4,5-dihydroisoxazole

: 1448793-05-2
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 1 h / -78 °C

1.2: 1 h / -78 - 70 °C

2.1: Chiralpack AD / n-heptane; ethanol / Resolution of racemate

3.1: palladium 10% on activated carbon; ammonium formate / ethanol / 5 h / 22 °C

4.1: ethanol; acetonitrile / 15 h / 85 °C / Sealed tube

5.1: sulfuric acid / 22 °C

5.2: 1.33 h / 0 °C

6.1: palladium 10% on activated carbon; hydrogen; triethylamine / ethanol / 2 h / 22 °C

7.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 20 h / 25 °C / Inert atmosphere

With n-butyllithium; sulfuric acid; palladium 10% on activated carbon; hydrogen; ammonium formate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethanol; hexane; n-heptane; ethyl acetate; toluene; acetonitrile;