benzyl-quinolin-6-yl-amine

Base Information

• Chemical Name: benzyl-quinolin-6-yl-amine
• CAS No.: 1068160-53-1
• Molecular Formula: C₁₆H₁₄N₂
• Molecular Weight: 234.301
• Mol file: 1068160-53-1.mol

Synonyms:benzyl-quinolin-6-yl-amine

Chemical Property of benzyl-quinolin-6-yl-amine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of benzyl-quinolin-6-yl-amine

There total 9 articles about benzyl-quinolin-6-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-chloroquinoline (612-57-7) + benzylamine (100-46-9) → benzyl-quinolin-6-yl-amine (1068160-53-1)

Guidance literature:

With copper(l) iodide; C₁₄H₁₆N₂O; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c02672

Reference yield: 92.0%

→ benzyl-quinolin-6-yl-amine (1068160-53-1)

Guidance literature:

With copper(l) iodide; C₁₄H₁₆N₂O; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 24h; Sealed tube; Inert atmosphere;

Reference yield: 91.0%

6-aminoquinoline (580-15-4) + benzyl alcohol (100-51-6,185532-71-2) → benzyl-quinolin-6-yl-amine (1068160-53-1)

Guidance literature:

With palladium diacetate; sodium 3-(diphenylphosphanyl)benzenesulfonate; In water; at 120 ℃; for 18h; Sealed tube;

DOI:10.1002/ejoc.201901606

upstream raw materials:

quinolin-6-yl 4-methylbenzene-1-sulfonate

benzylamine

6-hydroxyquinoline

N-benzyl-2-chloroacetamide

Refernces

• 1、 Bernhardson, David J.,Widlicka, Daniel W.,Singer, Robert A.. "Cu-Catalyzed Couplings of Heteroaryl Primary Amines and (Hetero)aryl Bromides with 6-Hydroxypicolinamide Ligands". . p. 1538 - 1551. Retrieved 2019.
• 2、 Chen, Xiahong,He, Yongqiang,Liang, Yun,Liu, Wenjie,Wang, Deping,Xia, Xiaohong,Xu, Jiamin,Xu, Zhifeng,Zhang, Fuxing,Zhang, Xin. "CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines". supporting information. p. 7486 - 7490. Retrieved 2020/10/12.