METHYL 4-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,4-DIHYDRO-3-PYRIDAZINECARBOXYLATE

Base Information

• Chemical Name: METHYL 4-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,4-DIHYDRO-3-PYRIDAZINECARBOXYLATE
• CAS No.: 478063-65-9
• Molecular Formula: C₁₃H₉F₃N₂O₃
• Molecular Weight: 298.221
• Mol file: 478063-65-9.mol

Synonyms:methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate

Chemical Property of METHYL 4-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,4-DIHYDRO-3-PYRIDAZINECARBOXYLATE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

METHYL-4-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,4-DIHYDRO-3-PYRIDAZINECARBOXYLATE 95.00% ^*data from reagent suppliers

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Technology Process of METHYL 4-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,4-DIHYDRO-3-PYRIDAZINECARBOXYLATE

There total 3 articles about METHYL 4-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,4-DIHYDRO-3-PYRIDAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate (339018-16-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (478063-65-9)

Guidance literature:

for 2h; Reflux;

Reference yield:

3-trifluoromethylaniline (98-16-8) → methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (478063-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; sodium acetate; hydrogenchloride / water; ethanol / 0.17 h / 0 °C

2: 2 h / Reflux

With hydrogenchloride; sodium acetate; sodium nitrite; In ethanol; water;

DOI:10.1021/jm5013648

Reference yield:

acetoacetic acid methyl ester (105-45-3) → methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (478063-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; sodium acetate; hydrogenchloride / water; ethanol / 0.17 h / 0 °C

2: 2 h / Reflux

With hydrogenchloride; sodium acetate; sodium nitrite; In ethanol; water;

DOI:10.1021/jm5013648

upstream raw materials:

methyl 3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

N,N-dimethyl-formamide dimethyl acetal

acetoacetic acid methyl ester

3-trifluoromethylaniline

Downstream raw materials:

4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylic acid

4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carbohydrazide

4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxamide

4-oxo-N-phenyl-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxamide

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