1-(2-Chloro-5-(hydroxy(oxido)amino)phenyl)-3H-[1,3]thiazolo[3,4-a]benz imidazole

Base Information

• Chemical Name: 1-(2-Chloro-5-(hydroxy(oxido)amino)phenyl)-3H-[1,3]thiazolo[3,4-a]benz imidazole
• CAS No.: 138226-16-1
• Molecular Formula: C15H10 Cl N3 O2 S
• Molecular Weight: 331.782
• Mol file: 138226-16-1.mol

Synonyms:1-(2-Chloro-5-(hydroxy(oxido)amino)phenyl)-3H-[1,3]thiazolo[3,4-a]benz imidazole

Chemical Property of 1-(2-Chloro-5-(hydroxy(oxido)amino)phenyl)-3H-[1,3]thiazolo[3,4-a]benz imidazole

Chemical Property:

• Vapor Pressure: 8.84E-12mmHg at 25°C
• Boiling Point: 554.8°Cat760mmHg
• Flash Point: 289.3°C
• PSA: 88.94000
• Density: 1.62g/cm³
• LogP: 4.91480

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Chloro-5-(hydroxy(oxido)amino)phenyl)-3H-[1,3]thiazolo[3,4-a]benz imidazole

There total 1 articles about 1-(2-Chloro-5-(hydroxy(oxido)amino)phenyl)-3H-[1,3]thiazolo[3,4-a]benz imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

mercaptoacetic acid (68-11-1) + 1,2-diamino-benzene (95-54-5) + 2-chloro-5-nitrobenzaldehyde (6361-21-3) → 1-(2-Chloro-5-nitro-phenyl)-3H-benzo[4,5]imidazo[1,2-c]thiazole (138226-16-1)

Guidance literature:

In benzene; 1) r.t., 2) 48 h, reflux;

upstream raw materials:

mercaptoacetic acid

1,2-diamino-benzene

2-chloro-5-nitrobenzaldehyde

Refernces

• 1、 Chimirri,Grasso,Monforte,Monforte,Zappala. "Anti-HIV agents II. synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles". . p. 925 - 933. Retrieved 2007/10/02.