dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

Base Information

Chemical Name:dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate
CAS No.:1312438-42-8
Molecular Formula:C₂₈H₃₀NO₁₂PS
Molecular Weight:635.585
Hs Code.:

Synonyms:dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

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Chemical Property of dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

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Technology Process of dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

There total 4 articles about dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1312438-73-5
dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[tertbutyl(dimethyl)silyl]oxy}pentanedioate

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1312438-42-8
dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

Guidance literature:: dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[tertbutyl(dimethyl)silyl]oxy}pentanedioate; With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Cooling with ice;

With boric acid; potassium hydroxide; In tetrahydrofuran; water; pH=7; Cooling with ice;

4-Nitrobenzenesulfonyl chloride; With pyridine; silver trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; for 48h; Cooling with ice;

Reference yield:

: 4224-69-5
methyl 2-(bromomethyl)propenoate

: 1312438-42-8
dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; indium / water; methanol / 4 h / 5 - 35 °C

2.1: 1-methyl-1H-imidazole / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 62 h / 20 - 90 °C

4.1: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 0 - 20 °C / Cooling with ice

4.2: pH 7 / Cooling with ice

4.3: 48 h / 0 - 20 °C / Cooling with ice

With 1-methyl-1H-imidazole; hydrogenchloride; indium; potassium carbonate; pyridine hydrogenfluoride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1312438-71-3
dimethyl (RS)-2-{[tert-butyl(dimethyl)silyl]oxy}-4-methylenepentanedioate

: 1312438-42-8
dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[(4-nitrophenyl)sulfonyl]oxy}pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 62 h / 20 - 90 °C

2.1: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 0 - 20 °C / Cooling with ice

2.2: pH 7 / Cooling with ice

2.3: 48 h / 0 - 20 °C / Cooling with ice

With potassium carbonate; pyridine hydrogenfluoride; In tetrahydrofuran; N,N-dimethyl-formamide;