2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide
CAS No.:1350923-88-4
Molecular Formula:C₁₅H₁₉BrF₃NO₂
Molecular Weight:382.221
Hs Code.:

Synonyms:2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

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Chemical Property of 2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

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Technology Process of 2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

There total 5 articles about 2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1350923-88-4
2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 65 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: hydrogenchloride; water / 1,4-dioxane / Inert atmosphere

5: triethylamine / 1,4-dioxane / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; water; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 3: Grignard reaction;
DOI:10.1021/jo2019653

Reference yield:

: 328-89-2
2-bromo-4-trifluoromethyl-benzoic acid

: 1350923-88-4
2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane / 2 h / 0 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo2019653

Reference yield:

: 58561-04-9
N-tert-butoxycarbonyl-L-valine methyl ester

: 1350923-88-4
2-bromo-N-((S)-2-hydroxy-2,4-dimethylpentan-3-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride; water / 1,4-dioxane / Inert atmosphere

3: triethylamine / 1,4-dioxane / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1: Grignard reaction;
DOI:10.1021/jo2019653