58561-04-9

Basic information

• Product Name: BOC-VAL-OME
• Synonyms: (S)-methyl 2-(tert-butoxycarbonylamino)-3-methylbutanoate;N-t-butoxycarbonyl-L-valine Methyl ester;N-Boc-L-valine Methyl ester, 97%;Methyl N-(tert-butoxycarbonyl)-L-valinate;L-Valine,N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester;Boc-L-Val-OMe;N-tert-Butoxycarbonylvaline methyl este;BOC-L-VALINE METHYL ESTER
• CAS NO: 58561-04-9
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.29
• Product Categories: Amino Acid Derivatives;Peptide Synthesis;Valine
• Mol File: 58561-04-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 194℃
• Boiling Point: 194 °C(lit.)
• Flash Point: 113 °C
• Appearance: /Liquid
• Density: 1.004 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: n20/D 1.44(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.13±0.46(Predicted)
• CAS DataBase Reference: BOC-VAL-OME(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-VAL-OME(58561-04-9)
• EPA Substance Registry System: BOC-VAL-OME(58561-04-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 58561-04-9(Hazardous Substances Data)

Usage

Uses

Boc-L-Val-OMe is an intermediate used in the asymmetric synthesis of isoxazoline and hydroxyketomethylene dipeptide isosteres via dipolar nitrile oxide cycloaddition. It is also used to prepare nonsymmetric dihydroxyethylene dipeptide isosteres via epoxyalcohols derived from α-amino acids.

InChI:InChI=1/C11H21NO4/c1-7(2)8(9(13)15-6)12-10(14)16-11(3,4)5/h7-8H,1-6H3,(H,12,14)/t8-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 134306-34-6 N-(Benzyloxycarbonyl)valine methyl ester 
• 67-56-1 methanol 
• 13734-41-3 N-Boc-(S/R)-valine 
• 189889-88-1 (2R,5S)-2-(4-Cyanobenzyl)-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine 
• 100-36-7 N,N-diethylethylenediamine 
• 395647-19-5 N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]benzoyl}-N-tert-butyloxycarbonylvaline methyl ester 
• 4070-48-8 D-Valine methyl ester 
• 58561-04-9 N-Boc-valine methyl ester 
• 74-88-4 methyl iodide 
• 5619-05-6 DL-valine methyl ester hydrochloride 

Downstream Products

• 103542-47-8 Boc-Val-CH2Cl 
• 157035-77-3 tert-butyl (S)-(2-hydroxy-2,4-dimethylpentan-3-yl)carbamate 
• 327600-47-5 (RS)-N-(t-Butylcarboxy)-3-amino-4-methylpentan-2-one 
• 69209-72-9 (N-tert-butoxycarbonyl-L-valyl)-L-valine 
• 108334-64-1 N-tert-butyloxycarbonyl-L-valyl-L-phenylalanine 
• 3339-44-4 methyl N-methyl-L-valinate hydrochloride 
• 66447-55-0 ((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 900187-89-5 (S)-methyl N-benzyl-N-(tert-butoxycarbonyl)valinate 
• 1130247-49-2 (2S)-2-tert-butyloxycarbonylamino-1,1-di(2-methoxy-5-methylphenyl)-3-methyl-1-butanol 
• 1244042-25-8 C₂₂H₃₅NO₄Si 
• 1300008-53-0 C₁₆H₂₅N₃O₂ 
• 1300008-54-1 C₂₁H₃₁N₃O₄ 
• 1309882-65-2 C₃₈H₅₉N₅O₁₀ 
• 6306-52-1 L-valine methylester hydrochloride 

Relevant articles and documents

Bioproduction of l-2-Aminobutyric Acid by a Newly-Isolated Strain of Aspergillus tamarii ZJUT ZQ013

Abstract: l-2-Aminobutyric acid (l-ABA), an unnatural amino acid, is a key intermediate of several important drugs. Although some methods have been developed to prepare pure chiral l-ABA, there are still many drawbacks, including low catalytic efficiency, cumbersome steps and high cost due to the addition of some expensive catalysts or coenzymes. Herein, with chemical and biological approaches together, we discovered a newly isolated Aspergillus tamarii ZJUT ZQ013 strain containing a microbial lipase which could be employed to resolve racemic methyl N-Boc-2-aminobutyrate to produce l-ABA with high enantioselectivity (e.e.s?>?99.9%, E = 257). Moreover, the subsequent gram scale experiment confrimed that A. tamarii ZJUT ZQ013 could be an attractive biocatalyst for the efficient preparation of optically pure acid. Graphical Abstract: [Figure not available: see fulltext.]

Enantiomeric resolution of α-amino acid derivatives on two diastereomeric chiral stationary phases based on chiral crown ethers incorporating two different chiral units

Two diastereomeric chiral stationary phases (CSPs) were applied to the liquid chromatographic resolution of various racemic a-amino methyl esters, α-amino N,N-diethylamides and α-amino N-propylamides. The CSP incorporating (R)-3,3' -diphenyl-1,1' -binaphtyl and (R,R)-tartaric acid unit as chiral barriers did not show any chiral recognition. In contrast, the CSP incorporating (R)-3,3'-diphenyl-1,1'-binaphtyl and (S,S)-tartaric acid unit as chiral barriers was found to show excellent chiral recognition especially for the two enantiomers of a-amino N-propylamides. Some of a-amino methyl esters and α-amino N,N-diethylamides were also resolved on the CSP incorporating (R)-3,3'-diphenyl-1,1'-binaphtyl and (S,S)-tartaric acid unit. From these results it was concluded that the two chiral units composing the diastereomeric CSPs can show "matched" or "mismatched" effect on the chiral recognition according to their absolute stereochemistry.

Direct organo-catalytic asymmetric α-amination of aldehydes - A simple approach to optically active α-amino aldehydes, α-amino alcohols, and α-amino acids

L-Proline as the catalyst: The first direct asymmetric α-amination of aldehydes using L-proline as the catalyst is presented (see scheme; Pg = protecting group). This new reaction gives easy access to optically active α-amino aldehydes, α-amino alcohols, and α-amino acids from simple and easily available starting materials and catalysts. The reactions proceed in high yields and excellent enantioselectivities with as little as 2 mol % of the catalyst.