4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

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Chemical Name:4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol
CAS No.:1442371-71-2
Molecular Formula:C₂₉H₃₂N₆O₂S
Molecular Weight:528.678
Hs Code.:

Synonyms:4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

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Chemical Property of 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

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Technology Process of 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

There total 2 articles about 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1401710-57-3
10-((1E,3Z)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)buta-1,3-dien-1-yl)-2-(piperidin-1-yl)-10H-phenothiazine

: 1442371-71-2
4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

Guidance literature:: 10-((1E,3Z)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)buta-1,3-dien-1-yl)-2-(piperidin-1-yl)-10H-phenothiazine; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

With dihydrogen peroxide; sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 110-89-4
piperidine

: 742105-63-1
2-chloro-10-((1E,3Z)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)buta-1,3-dien-1-yl)-10H-phenothiazine

: 1442371-71-2
4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-piperidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: XPhos / toluene / 80 - 110 °C / Inert atmosphere; Alkaline conditions

2.1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 20 °C

2.2: 24 h / 0 - 20 °C

With dimethylsulfide borane complex; XPhos; In tetrahydrofuran; toluene; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034