2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

Base Information

Chemical Name:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile
CAS No.:1263941-07-6
Molecular Formula:C₂₁H₁₅ClN₄
Molecular Weight:358.83
Hs Code.:

Synonyms:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

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Chemical Property of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

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Technology Process of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

There total 2 articles about 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84831-51-6
2-acetyl-3-phenylpropanenitrile

: 57999-09-4
5-amino-4-(4-chlorophenyl)-1Н-pyrazole

: 1263941-07-6
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 150 ℃; for 0.5h;

Reference yield:

: 645-59-0
dihydrocinnamonitrile

: 1263941-07-6
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.75 h / 20 °C / Cooling with acetone-dry ice

1.2: 0.5 h

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.5 h / 150 °C

With hydrogenchloride; n-butyllithium; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 1263941-07-6
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

: 108-24-7
acetic anhydride

: 64-19-7,77671-22-8
acetic acid

: 1264295-36-4
3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

Guidance literature:: 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile; With hydroxylamine N-hydroxysuccinimide; In methanol; water; at 80 ℃; Sealed vessel;

acetic anhydride; In 1,4-dioxane; at 120 ℃; for 2h;

acetic acid; In 1,4-dioxane; at 120 ℃; for 72h;