3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

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Chemical Name:3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole
CAS No.:1264295-36-4
Molecular Formula:C₂₃H₁₈ClN₅O
Molecular Weight:415.882
Hs Code.:

Synonyms:3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

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Chemical Property of 3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

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Technology Process of 3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

There total 3 articles about 3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263941-07-6
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile

: 108-24-7
acetic anhydride

: 64-19-7,77671-22-8
acetic acid

: 1264295-36-4
3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

Guidance literature:: 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-phenylpropanenitrile; With hydroxylamine N-hydroxysuccinimide; In methanol; water; at 80 ℃; Sealed vessel;

acetic anhydride; In 1,4-dioxane; at 120 ℃; for 2h;

acetic acid; In 1,4-dioxane; at 120 ℃; for 72h;

Reference yield:

: 645-59-0
dihydrocinnamonitrile

: 1264295-36-4
3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.75 h / 20 °C / Cooling with acetone-dry ice

1.2: 0.5 h

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.5 h / 150 °C

3.1: hydroxylamine N-hydroxysuccinimide / water; methanol / 80 °C / Sealed vessel

3.2: 2 h / 120 °C

3.3: 72 h / 120 °C

With hydrogenchloride; n-butyllithium; hydroxylamine N-hydroxysuccinimide; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;

Reference yield:

: 84831-51-6
2-acetyl-3-phenylpropanenitrile

: 1264295-36-4
3-(1-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-phenylethyl)-5-methyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.5 h / 150 °C

2.1: hydroxylamine N-hydroxysuccinimide / water; methanol / 80 °C / Sealed vessel

2.2: 2 h / 120 °C

2.3: 72 h / 120 °C

With hydrogenchloride; hydroxylamine N-hydroxysuccinimide; In 1,4-dioxane; methanol; ethanol; water;