5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Base Information

• Chemical Name: 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole
• CAS No.: 1612254-46-2
• Molecular Formula: C₂₇H₂₈N₆O
• Molecular Weight: 452.559
• Mol file: 1612254-46-2.mol

Synonyms:5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Chemical Property of 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

There total 18 articles about 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde (129012-05-1) + C13H20N4 → 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole (1612254-46-2)

Guidance literature:

With sodium metabisulfite; In ethanol; water; for 24h; Reflux;

DOI:10.1021/jm5003028

Reference yield:

N-(5-chloro-2-nitrophenyl)acetamide (5443-33-4) → 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole (1612254-46-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dimethyl sulfoxide / 120 °C

2: sulfuric acid / 80 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 °C / 2068.65 Torr

4: sodium metabisulfite / water; ethanol / 24 h / Reflux

With sodium metabisulfite; sulfuric acid; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1021/jm5003028

Reference yield:

2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde (129012-05-1) + C13H22N4 → 5-(4-propylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole (1612254-46-2)

Guidance literature:

With sodium metabisulfite; In water; for 12h; Reflux;

DOI:10.1016/j.bmc.2016.06.010

upstream raw materials:

1-allylpiperazine

5-(4-allyl-1-piperazinyl)-2-nitroaniline

N-(5-chloro-2-nitrophenyl)acetamide

2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde