7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Base Information

Chemical Name:7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide
CAS No.:1392841-65-4
Molecular Formula:C₂₀H₁₆N₄O₃
Molecular Weight:360.372
Hs Code.:

Synonyms:7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Suppliers and Price of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

There total 4 articles about 7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-24-5
7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 765-30-0
Cyclopropylamine

: 1392841-65-4
7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Guidance literature:: In tetrahydrofuran; ethanol; at 80 ℃; for 4h; Sealed tube;

Reference yield:

: 174740-68-2
5-dimethylamino-3-ethoxycarbonyl-2-methoxycarbonyl-penta-2,4-dienoic acid methyl ester

: 1392841-65-4
7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 5 h / Reflux

2.1: pyridine; lithium iodide / 1 h / Reflux

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

3.2: 16 h / 20 °C

3.3: 16 h / 20 °C

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol

5.2: pH 4

6.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

7.1: N,N-dimethyl-formamide / 0.13 h / Reflux; Inert atmosphere

8.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1392839-21-2
1-benzyl-3-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid ethyl ester

: 1392841-65-4
7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acidcyclopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol

1.2: pH 4

2.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

3.1: N,N-dimethyl-formamide / 0.13 h / Reflux; Inert atmosphere

4.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Sealed tube

With sodium methylate; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;