(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

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Chemical Name:(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester
CAS No.:499239-04-2
Molecular Formula:C₄₇H₅₂N₅O₉P
Molecular Weight:861.932
Hs Code.:

(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

Synonyms:(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

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Chemical Property of (4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

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Technology Process of (4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

There total 12 articles about (4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1592-20-7,29296-32-0
4-Vinylbenzyl chloride

: 499239-04-2
(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / -78 °C

1.2: tetra-n-butylammonium iodide / -78 - 20 °C

2.1: aq. OsO₄; NMO / tetrahydrofuran

3.1: aq. NaIO₄ / tetrahydrofuran

4.1: 79 percent / Ti(OiPr)4 / Heating

5.1: n-BuLi / tetrahydrofuran

5.2: 83 percent / ClTi(OiPr)3 / tetrahydrofuran

6.1: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 20 °C

7.1: 57 percent / HOBt; diisopropyl-carbodiimide / dimethylformamide

8.1: 100 percent / HCl / dioxane; methanol

9.1: HOBt; diisopropyl-carbodiimide / dimethylformamide

With titanium(IV) isopropylate; hydrogenchloride; lithium hydroxide; sodium periodate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00783-7

Reference yield:

: 499238-98-1
(4-formyl-benzyl)-phosphonic acid dibenzyl ester

: 499239-04-2
(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 79 percent / Ti(OiPr)4 / Heating

2.1: n-BuLi / tetrahydrofuran

2.2: 83 percent / ClTi(OiPr)3 / tetrahydrofuran

3.1: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 20 °C

4.1: 57 percent / HOBt; diisopropyl-carbodiimide / dimethylformamide

5.1: 100 percent / HCl / dioxane; methanol

6.1: HOBt; diisopropyl-carbodiimide / dimethylformamide

With titanium(IV) isopropylate; hydrogenchloride; lithium hydroxide; n-butyllithium; benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00783-7

Reference yield:

: 562098-62-8
(S)-2-[(1-Amino-cyclohexanecarbonyl)-amino]-succinamide

: 499239-04-2
(4-{(S)-2-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-1-[2-(naphthalen-2-yloxy)-acetylamino]-ethyl}-benzyl)-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / HOBt; diisopropyl-carbodiimide / dimethylformamide

2: 100 percent / HCl / dioxane; methanol

3: HOBt; diisopropyl-carbodiimide / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; diisopropyl-carbodiimide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00783-7