(3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Base Information

Chemical Name:(3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
CAS No.:1593542-96-1
Molecular Formula:C₂₄H₂₁F₂NO₃
Molecular Weight:409.432
Hs Code.:
Mol file:1593542-96-1.mol

Synonyms:C₂₄H₂₁F₂NO₃

Suppliers and Price of (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3R,4R,3’R)-Ezetimibe
5mg
$ 1850.00

Total 14 raw suppliers

Chemical Property of (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Chemical Property:

Melting Point:>74°C (dec.)
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(3R,4R,3’R)-Ezetimibe ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3’R,3R,4R)-Ezetimibe is a structural analog of Ezetimibe (E975000); an antihyperlipoproteinemic and a cholesterol absorption inhibitor.

Technology Process of (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

There total 3 articles about (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

: (3R,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

: 1593542-96-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
C₂₄H₂₁F₂NO₃

Guidance literature:: With dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; at -5 ℃;
DOI:10.1016/j.cclet.2014.03.035

Reference yield:

: 1478663-95-4
(S)-3-((R)-2-((R)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-4-(2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one

: 1593542-96-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
C₂₄H₂₁F₂NO₃

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride; N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 25 °C

2: sulfuric acid / isopropyl alcohol / 50 °C

3: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / dichloromethane / -5 °C

With N,O-bis-(trimethylsilyl)-acetamide; dimethylsulfide borane complex; sulfuric acid; tetrabutyl ammonium fluoride; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.cclet.2014.03.035

Reference yield:

: (3R,4R)-4-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1-(4-fluorophenyl)-3-(2-(2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl)ethyl)azetidin-2-one

: 1593542-96-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
C₂₄H₂₁F₂NO₃

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / isopropyl alcohol / 50 °C

2: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / dichloromethane / -5 °C

With dimethylsulfide borane complex; sulfuric acid; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.cclet.2014.03.035