3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

Base Information

Chemical Name:3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide
CAS No.:1300022-76-7
Molecular Formula:C₂₂H₁₅F₄N₃O
Molecular Weight:413.374
Hs Code.:

Synonyms:3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

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Chemical Property of 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

Chemical Property:

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Technology Process of 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

There total 4 articles about 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38749-79-0
3-bromo-2-picoline

: 1300022-76-7
3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 31 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 24 h / Reflux

3.1: trichlorophosphate / Reflux

3.2: Cooling with ice

4.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 3 h / 140 °C / 11251.1 Torr

With N-Bromosuccinimide; sodium hydride; triethylamine; trichlorophosphate; dibenzoyl peroxide; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; In tetrahydrofuran; tetrachloromethane; toluene; mineral oil;

Reference yield:

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 201230-82-2
carbon monoxide

: 1300022-22-3
8-bromo-3-(4-fluorophenyl)-imidazo[1,5-a]pyridine

: 1300022-76-7
3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

Guidance literature:: With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; In toluene; at 140 ℃; for 3h; under 11251.1 Torr;

Reference yield:

: 1300022-20-1
N-(3-bromopyridin-2-ylmethyl)-4-fluoro-benzamide

: 1300022-76-7
3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid 3-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / Reflux

1.2: Cooling with ice

2.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 3 h / 140 °C / 11251.1 Torr

With triethylamine; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; In toluene;