methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester
CAS No.:663602-54-8
Molecular Formula:C₂₃H₂₈N₂O₆
Molecular Weight:428.485
Hs Code.:

methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

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Chemical Property of methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

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Technology Process of methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

There total 13 articles about methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 663602-45-7
[1-[4-(2-hydroxy-ethyl)-phenyl]-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

: 663602-54-8
methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; at 20 ℃; for 2h;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 663602-54-8
methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

2: 820 mg / NaOH / methanol; H₂O / 0.5 h / 65 °C

3: 838 mg / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4: 323 mg / triphenylarsine; LiCl / Pd₂(dba)3*CHCl₃ / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

5: tetrahydrofuran / 3 h / 20 °C

6: 212 mg / NaOH; H₂O₂ / H₂O; tetrahydrofuran / 0.5 h / 20 °C

7: 36 percent / Et₃N; DMSO; sulfur trioxide pyridine complex / 2 h / 20 °C

With pyridine; sodium hydroxide; triphenyl-arsane; dihydrogen peroxide; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; toluene; 1: Mitsunobu reaction / 4: Stille reaction;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 663602-54-8
methyl-{3-(4-nitro-phenoxy)-1-[4-(2-oxo-ethyl)-phenyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: ethanol / 2 h / 90 °C

2: sulfuric acid / 6 h / 80 °C

3: tetrahydrofuran / 12 h / 20 °C

4: K₂CO₃ / dimethylformamide / 3 h / 20 °C

5: LiAlH₄ / tetrahydrofuran / 0.17 h / -20 - -10 °C

6: PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

7: 820 mg / NaOH / methanol; H₂O / 0.5 h / 65 °C

8: 838 mg / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

9: 323 mg / triphenylarsine; LiCl / Pd₂(dba)3*CHCl₃ / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

10: tetrahydrofuran / 3 h / 20 °C

11: 212 mg / NaOH; H₂O₂ / H₂O; tetrahydrofuran / 0.5 h / 20 °C

12: 36 percent / Et₃N; DMSO; sulfur trioxide pyridine complex / 2 h / 20 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; triphenyl-arsane; sulfuric acid; dihydrogen peroxide; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6: Mitsunobu reaction / 9: Stille reaction;