methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate

Base Information

Chemical Name:methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate
CAS No.:697789-47-2
Molecular Formula:C₁₈H₂₅NO₄S
Molecular Weight:351.467
Hs Code.:

Synonyms:methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate

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Technology Process of methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate

There total 2 articles about methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 106-95-6
allyl bromide

: 697789-43-8
methyl (3R)-3-[(benzyloxy)carbonylamino]-5-methylsulfanylpentanoate

: 697789-47-2
methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate

Guidance literature:: With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 18h;
DOI:10.1021/jo049794g

Reference yield:

: 1152-62-1
Cbz-Met-OH

: 697789-47-2
methyl (2S)-2-[(1S)-1-(benzyloxy)carbonylamino-3-methylsulfanylpropyl]-4-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; ClCO₂Et / tetrahydrofuran / 0.25 h / -15 °C

1.2: tetrahydrofuran; diethyl ether / 0 °C

1.3: 93 percent / silver benzoate; triethylamine / -25 °C

2.1: 53 percent / LDA; LiCl / tetrahydrofuran / 18 h / -78 - 20 °C

With chloroformic acid ethyl ester; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo049794g