3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

Base Information

Chemical Name:3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione
CAS No.:1053265-47-6
Molecular Formula:C₂₁H₂₂N₂O₃
Molecular Weight:350.417
Hs Code.:

Synonyms:3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

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Chemical Property of 3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

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Technology Process of 3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

There total 9 articles about 3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053265-46-5
9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

: 100-39-0
benzyl bromide

: 1053265-47-6
3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

Guidance literature:: 9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 16.5h;

Reference yield:

: 912361-07-0
N,6-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-amine

: 1053265-47-6
3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 1.67 h / 0 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 16 h / 60 °C

3.1: sodium hydroxide; ozone / dichloromethane / -78 °C

4.1: hydrogenchloride / 1,4-dioxane

5.1: pyridine / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 10 h / 50 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C

7.2: 16.5 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; ammonium formate; sodium hydride; potassium carbonate; ozone; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1053265-40-9
7-methoxy-2-vinyl-2,3,4,5-tetrahydro-1H-1-benzazepine

: 1053265-47-6
3-benzyl-9-methoxy-2,3,4a,5,6,7-hexahydropyrazino[1,2-a][l]benzazepine-1,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrahydrofuran / 16 h / 60 °C

2.1: sodium hydroxide; ozone / dichloromethane / -78 °C

3.1: hydrogenchloride / 1,4-dioxane

4.1: pyridine / tetrahydrofuran / 18 h / 0 - 20 °C

5.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 10 h / 50 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C

6.2: 16.5 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; ammonium formate; sodium hydride; potassium carbonate; ozone; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;