4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide

Base Information

• Chemical Name: 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide
• CAS No.: 191168-77-1
• Molecular Formula: C₂₂H₂₉N₃O₂
• Molecular Weight: 367.491
• Mol file: 191168-77-1.mol

Synonyms:4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide

Chemical Property of 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide

There total 2 articles about 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-aniline (104-94-9) → 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide (191168-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / (C₂H₅)3N / benzene

2: NaI / dimethylformamide

With triethylamine; sodium iodide; In N,N-dimethyl-formamide; benzene;

DOI:10.3987/com-97-7736

Reference yield:

1-phenylmethylpiperazine (2759-28-6) + N-(p-methoxyphenyl)-4-chlorobutyramide (173345-91-0) → 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide (191168-77-1)

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide;

DOI:10.3987/com-97-7736

Reference yield: 83.0%

4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide (191168-77-1) → 4-(4-Benzyl-piperazin-1-yl)-N-(4-methoxy-phenyl)-butyramide; hydrochloride

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.3987/com-97-7736

upstream raw materials:

1-phenylmethylpiperazine

N-(p-methoxyphenyl)-4-chlorobutyramide

4-methoxy-aniline

Downstream raw materials:

N-(4-Methoxy-phenyl)-4-piperazin-1-yl-butyramide