N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

Base Information

Chemical Name:N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide
CAS No.:1361380-94-0
Molecular Formula:C₁₇H₁₈N₄O₃
Molecular Weight:326.355
Hs Code.:

N<sub>6</sub>-benzyl-N<sub>2</sub>-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

Synonyms:N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

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Chemical Property of N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

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Technology Process of N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

There total 4 articles about N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1361381-52-3
methyl 6-(benzylcarbamoyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate

: 1361380-94-0
N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

Guidance literature:: methyl 6-(benzylcarbamoyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate; With hydroxylamine potassium salt; In methanol; at 20 ℃; for 13h;

With acetic acid; In methanol;

Reference yield:

: 1361381-49-8
methyl 6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate hydrochloride

: 1361380-94-0
N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium(II) hydroxide / methanol / 13 h / 20 °C / 760.05 Torr / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 13 h / 20 °C

3: hydroxylamine potassium salt / methanol / 13 h / 20 °C

With hydroxylamine potassium salt; hydrogen; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1160995-15-2
6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylic acid

: 1361380-94-0
N₆-benzyl-N₂-hydroxy-7,8-dihydro-1,6-naphthyridine-2,6(5H)-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 13 h / 80 °C / Sealed tube

2: hydrogen / palladium(II) hydroxide / methanol / 13 h / 20 °C / 760.05 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 13 h / 20 °C

4: hydroxylamine potassium salt / methanol / 13 h / 20 °C

With hydrogenchloride; hydroxylamine potassium salt; hydrogen; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;