trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

Base Information

Chemical Name:trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]
CAS No.:400899-26-5
Molecular Formula:C₁₄H₂₄N₂O₂
Molecular Weight:252.357
Hs Code.:

Synonyms:trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

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Chemical Property of trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

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Technology Process of trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

There total 5 articles about trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: potassium cyanide

: ((1R,4r)-4-((tert-butoxycarbonyl)(methyl)amino)cyclohexyl)methyl methanesulfonate

: 400899-26-5
trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

Guidance literature:: With potassium iodide; In dimethyl sulfoxide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 4-methylbenzene sulfonyl chloride

: tert-butyl N-[4-(hydroxymethyl)cyclohexyl]-N-(methyl)carbamate

: trans-[Toluene-4-sulfonic acid 4-(tert-butoxycarbonyl-methyl-amino)-cyclohexylmethyl ester]

: 400899-26-5
trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

Guidance literature:: In pyridine; N,N-dimethyl-formamide;

Reference yield:

: 400899-07-2
methyl (1r,4r)‐4‐{[(tert‐butoxy)carbonyl](methyl)amino}cyclohexane‐1‐carboxylate

: 400899-26-5
trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran; methanol / 2 h / 0 - 50 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: potassium iodide / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere

With lithium borohydride; triethylamine; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;