tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

Base Information

Chemical Name:tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate
CAS No.:400899-28-7
Molecular Formula:C₁₄H₂₅NO₃
Molecular Weight:255.357
Hs Code.:

Synonyms:tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

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Chemical Property of tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

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Technology Process of tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

There total 5 articles about tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: DIBALH-solution

: 400899-26-5
trans-[(4-Cyanomethyl-cyclohexyl)-methyl-carbamic acid tert-butyl ester]

: 400899-28-7
tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; toluene;

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 400899-28-7
tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / 72 h / 20 °C / 3102.97 Torr

2.1: hydrogenchloride / water / 2 h / Reflux

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 80 h / 0 - 20 °C

5.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/acs.jmedchem.5b00581

Reference yield:

: 76308-28-6
ethyl 2‐[(1r,4r)‐4‐aminocyclohexyl]acetate

: 400899-28-7
tert-butyl methyl(trans-4-(2-oxoethyl)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 80 h / 0 - 20 °C

3.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/acs.jmedchem.5b00581