(E)-2-(4-methylphenyl)methylenecyclobutanone

Base Information

• Chemical Name: (E)-2-(4-methylphenyl)methylenecyclobutanone
• CAS No.: 1520990-16-2
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.227
• Mol file: 1520990-16-2.mol

Synonyms:(E)-2-(4-methylphenyl)methylenecyclobutanone

Chemical Property of (E)-2-(4-methylphenyl)methylenecyclobutanone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (E)-2-(4-methylphenyl)methylenecyclobutanone

There total 1 articles about (E)-2-(4-methylphenyl)methylenecyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

cyclobutanone (1191-95-3) + 4-methyl-benzaldehyde (104-87-0) → (E)-2-(4-methylphenyl)methylenecyclobutanone (1520990-16-2)

Guidance literature:

With 1-methyl-piperazine; L-proline; In ethanol; at 120 ℃; for 48h; Reagent/catalyst; Temperature; Catalytic behavior; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.09.088

Reference yield: 98.0%

(E)-2-(4-methylphenyl)methylenecyclobutanone (1520990-16-2) → (R,E)-2-(4-methylbenzylidene)cyclobutan-1-ol

Guidance literature:

With C₈₄H₈₀Cl₄N₂O₂P₄Ru₃; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 20 ℃; for 1h; under 1500.15 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.9b01514

Reference yield: 94.0%

(E)-2-(4-methylphenyl)methylenecyclobutanone (1520990-16-2) → (S, E)-2-(4-methylbenzylidene)cyclobutanol

Guidance literature:

With formic acid; (R)-Ru(η6-mesitylene)-(R,R)-TsDPEN; triethylamine; In chloroform; at 35 ℃; for 6h; chemoselective reaction; Schlenk technique; Green chemistry;

DOI:10.1039/d1gc00026h

upstream raw materials:

cyclobutanone

4-methyl-benzaldehyde