1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone

Base Information

Chemical Name:1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone
CAS No.:303104-77-0
Molecular Formula:C₁₅H₁₃FO₃
Molecular Weight:260.265
Hs Code.:
European Community (EC) Number:652-371-9
DSSTox Substance ID:DTXSID101190760

Synonyms:1-(2,4-dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone;Oprea1_180125;Oprea1_312036;DTXSID101190760;HMS1586L11;STK972300;AKOS003615662;303104-77-0;SR-01000241243;SR-01000241243-1;ethanone, 1-(2,4-dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)-

Suppliers and Price of 1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:260.08487243
Heavy Atom Count:19
Complexity:313

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1O)C(=O)CC2=CC=C(C=C2)F)O

Technology Process of 1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone

There total 1 articles about 1-(2,4-Dihydroxy-3-methylphenyl)-2-(4-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 608-25-3
2-methylbenzene-1,3-diol

: 405-50-5
p-Fluorophenylacetic acid

: 303104-77-0
2,4-dihydroxy-3-methylphenyl-4′-fluorobenzylketone

Guidance literature:: With boron trifluoride diethyl etherate; at 100 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.01.042

Reference yield: 75.0%

: 303104-77-0
2,4-dihydroxy-3-methylphenyl-4′-fluorobenzylketone

: 74-88-4
methyl iodide

: 315234-08-3
4'-fluoro-2-hydroxy-4-methoxy-3-methyldeoxybenzoin

Guidance literature:: With potassium carbonate; In acetone; for 6h; regioselective reaction; Reflux;
DOI:10.1016/j.bmc.2014.01.042

Reference yield:

: 303104-77-0
2,4-dihydroxy-3-methylphenyl-4′-fluorobenzylketone

: C₂₅H₂₀BrFO₅

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: pyridine / 5 h / 20 °C

3: glycerol / 2 h / 260 °C / Inert atmosphere

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Reflux

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; acetone; glycerol;
DOI:10.1016/j.bmc.2014.01.042