2-(3-methyloxetan-3-yl)acetic acid

Base Information

• Chemical Name: 2-(3-methyloxetan-3-yl)acetic acid
• CAS No.: 933727-35-6
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.144
• Hs Code.: 2932990090
• Mol file: 933727-35-6.mol

Synonyms:2-(3-methyloxetan-3-yl)acetic acid

Chemical Property of 2-(3-methyloxetan-3-yl)acetic acid

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-Methyloxetan-3-yl)acetic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Methyl-3-oxetaneacetic Acid is used in the synthesis of Nicotinamide Phosphoribosyltransferase Inhibitors. 2-(3-Methyloxetan-3-yl)acetic Acid is a reagent used in the synthesis of prodrugs for the treatment or prevention of CNS diseases. As well, used in the preparation of NAMPT inhibitors, as potential therapeutics for oncological diseases.

Technology Process of 2-(3-methyloxetan-3-yl)acetic acid

There total 2 articles about 2-(3-methyloxetan-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(3-methyloxetan-3-yl)acetate (1453272-38-2) → 2-(3-methyloxetan-3-yl)acetic acid (933727-35-6)

Guidance literature:

With water; sodium hydroxide; In methanol; at 40 ℃; for 12h;

Reference yield:

ethyl 2-(oxetan-3-ylidene)acetate (922500-91-2) → 2-(3-methyloxetan-3-yl)acetic acid (933727-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; chloro-trimethyl-silane / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

1.2: 1.17 h / -15 - 25 °C

2.1: water; sodium hydroxide / methanol / 12 h / 40 °C

With copper(l) iodide; chloro-trimethyl-silane; water; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield: 38.0%

2-(3-methyloxetan-3-yl)acetic acid (933727-35-6) + C15H17Cl2NO3 → (2-(3-methyloxetan-3-yl)acetoyloxy)methyl (R)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

Guidance literature:

With triethylamine; sodium iodide; In acetone; at 70 ℃; for 1h;

upstream raw materials:

ethyl 2-(oxetan-3-ylidene)acetate

ethyl 2-(3-methyloxetan-3-yl)acetate

Refernces