(S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester
CAS No.:179669-45-5
Molecular Formula:C₃₁H₄₀N₄O₈
Molecular Weight:596.681
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 119768-45-5,185525-63-7
(S)-2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

: 26348-68-5
N-(benzyloxycarbonyl)lysine methyl ester hydrochloride

: 179669-45-5
(S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 16h;

Reference yield:

: 179669-45-5
(S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

: 179669-59-1
(S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / dioxane / 2 h / Ambient temperature

2: 86 percent / DPPA / dimethylformamide / 48 h / -20 °C

3: 97 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

4: 97 percent / aq. NaOH / dioxane / Ambient temperature

5: EDC / CH₂Cl₂ / 16 h

6: HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 179669-45-5
(S)-2-Benzyloxycarbonylamino-6-[(S)-2-tert-butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

: 179669-58-0
C₅₇H₇₄F₅N₇O₁₂

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / dioxane / 2 h / Ambient temperature

2: 86 percent / DPPA / dimethylformamide / 48 h / -20 °C

3: 97 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

4: 97 percent / aq. NaOH / dioxane / Ambient temperature

5: EDC / CH₂Cl₂ / 16 h

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;