(S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

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Chemical Name:(S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester
CAS No.:179669-59-1
Molecular Formula:C₅₂H₆₆F₅N₇O₁₀
Molecular Weight:1044.13
Hs Code.:

(S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

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Chemical Property of (S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

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Technology Process of (S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

There total 11 articles about (S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179669-84-2
(S)-2-[((S)-2-Amino-4-methyl-pentanoyl)-methyl-amino]-4-methyl-pentanoic acid benzyl ester

: 179669-59-1
(S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / TBTU, Huenig's base / CH₂Cl₂ / 3 h / 0 °C

2: 98 percent / H₂ / Pd/C / methanol / 3 h / Ambient temperature

3: 86 percent / DPPA / dimethylformamide / 48 h / -20 °C

4: 97 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

5: 97 percent / aq. NaOH / dioxane / Ambient temperature

6: EDC / CH₂Cl₂ / 16 h

7: HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 179669-50-2
(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

: 179669-59-1
(S)-6-{(S)-2-((S)-2-{[(S)-2-((S)-2-Amino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-[5-(2,2-dimethyl-propionyloxy)-1H-indol-3-yl]-propionylamino}-2-benzyloxycarbonylamino-hexanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / H₂ / Pd/C / methanol / 3 h / Ambient temperature

2: 86 percent / DPPA / dimethylformamide / 48 h / -20 °C

3: 97 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

4: 97 percent / aq. NaOH / dioxane / Ambient temperature

5: EDC / CH₂Cl₂ / 16 h

6: HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;