5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one

Base Information

• Chemical Name: 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one
• CAS No.: 1330676-80-6
• Molecular Formula: C₂₁H₁₆F₂N₄O₃S₂
• Molecular Weight: 474.512

Synonyms:5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one

Chemical Property of 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one

Chemical Property:

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Technology Process of 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one

There total 3 articles about 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-thioxo-4-thiazolidinone (141-84-4) + 4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzaldehyde (1330676-37-3) → 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one (1330676-80-6)

Guidance literature:

With sodium acetate; In acetic acid; at 85 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole (86386-76-7,123632-22-4,141113-42-0,150024-48-9) → 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one (1330676-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / ethyl acetate / 12 h / 80 °C / Inert atmosphere

2: sodium acetate / acetic acid / 2 h / 85 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium acetate; potassium carbonate; In acetic acid; ethyl acetate;

DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-thioxothiazolidin-4-one (1330676-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / ethyl acetate / 12 h / 80 °C / Inert atmosphere

2: sodium acetate / acetic acid / 2 h / 85 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium acetate; potassium carbonate; In acetic acid; ethyl acetate;

DOI:10.1016/j.bmcl.2011.06.022

upstream raw materials:

2-thioxo-4-thiazolidinone

4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzaldehyde

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

4-hydroxy-benzaldehyde

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