2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

Base Information

Chemical Name:2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde
CAS No.:1398567-35-5
Molecular Formula:C₃₄H₂₅NO₃
Molecular Weight:495.577
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

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Chemical Property of 2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

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Technology Process of 2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

There total 3 articles about 2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1398567-19-5
2-iodo-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

: 5720-07-0
4-methoxyphenylboronic acid

: 1398567-35-5
2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo3015374

Reference yield:

: 1159765-59-9
2-(2-(p-tolyl)ethynyl)quinoline-3-carbaldehyde

: 1398567-35-5
2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; potassium carbonate / dichloromethane / 25 °C

2: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3: iodine / dichloromethane / 25 °C

4: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 2 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; iodine; potassium carbonate; diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling / 4: |Suzuki Coupling;
DOI:10.1021/jo3015374

Reference yield:

: 1398566-81-8
1-methoxy-4-(phenylethynyl)-3-(p-tolyl)-1H-pyrano[4,3-b]quinoline

: 1398567-35-5
2-(4-methoxyphenyl)-3-(4-methylbenzoyl)-1-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / dichloromethane / 25 °C

2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 2 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; iodine; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1021/jo3015374