benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

Base Information

Chemical Name:benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate
CAS No.:297181-03-4
Molecular Formula:C₃₁H₄₀N₃O₉P
Molecular Weight:629.647
Hs Code.:

Synonyms:benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

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Technology Process of benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

There total 5 articles about benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1147-76-8
5-(N-phthalimido)pentanoic acid

: benzyl (2R,S)-4-diethylphosphonyl-2-((L-alanyl)-amino)butanoate hydrochloride

: 297181-03-4
benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 25h;
DOI:10.1080/10426500008044997

Reference yield:

: 2-amino-4-(diethoxy-phosphoryl)-butyric acid benzyl ester

: 297181-03-4
benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; diphenylphosphorylazide / dimethylformamide / 25 h / 0 - 20 °C

2: 97 percent / HCl (g) / acetic acid / 2 h

3: 67 percent / diphenylphosphorylazide; Et₃N / dimethylformamide / 25 h / 0 - 20 °C

With hydrogenchloride; diphenylphosphoranyl azide; triethylamine; In acetic acid; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis / 3: Condensation;
DOI:10.1080/10426500008044997

Reference yield:

: 297180-99-5
benzyl (2R,S)-4-bromo-2-phthalimidobutanoate

: 297181-03-4
benzyl (2R,S)-4-diethylphosphonyl-2-(N-(5-phthalimidopentanoyl)-(L-alanyl)-amino)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / 10 h / Heating

2: hydrazine hydrate / ethanol / 72 h / 20 °C

3: Et₃N; diphenylphosphorylazide / dimethylformamide / 25 h / 0 - 20 °C

4: 97 percent / HCl (g) / acetic acid / 2 h

5: 67 percent / diphenylphosphorylazide; Et₃N / dimethylformamide / 25 h / 0 - 20 °C

With hydrogenchloride; diphenylphosphoranyl azide; hydrazine hydrate; triethylamine; In ethanol; acetic acid; N,N-dimethyl-formamide; 1: Substitution / 2: Elimination / 3: Condensation / 4: Hydrolysis / 5: Condensation;
DOI:10.1080/10426500008044997