(±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

Base Information

Chemical Name:(±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide
CAS No.:1448350-37-5
Molecular Formula:C₂₄H₂₃N₅O₂
Molecular Weight:413.479
Hs Code.:

Synonyms:(±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

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Chemical Property of (±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

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Technology Process of (±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

There total 5 articles about (±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1448350-34-2
1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

: 1448350-37-5
(±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm400634n

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1448350-37-5
(±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / acetonitrile / 18 h / 20 °C

2.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C / Inert atmosphere

3.1: ethanol / 18 h / Inert atmosphere; Reflux

4.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With pyridine; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400634n

Reference yield:

: 1448350-31-9
4-({[(±)-1-(tert-butoxycarbonyl)-5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl]amino}methyl)benzoic acid

: 1448350-37-5
(±)-N-(2-aminophenyl)-4-({(5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino}methyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm400634n